Annual report pursuant to Section 13 and 15(d)

Stockholders??? Equity (Details Narrative)

v3.22.1
Stockholders’ Equity (Details Narrative)
1 Months Ended 12 Months Ended
Nov. 01, 2021
shares
Oct. 06, 2021
USD ($)
shares
Aug. 20, 2021
USD ($)
Aug. 05, 2021
shares
Jul. 01, 2021
shares
Jun. 16, 2021
shares
Jun. 08, 2021
shares
Feb. 24, 2021
USD ($)
shares
Dec. 15, 2020
$ / shares
shares
Oct. 06, 2020
USD ($)
$ / shares
shares
Aug. 31, 2020
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Dec. 31, 2020
USD ($)
shares
Jan. 01, 2022
shares
Feb. 16, 2021
$ / shares
shares
Class of Stock [Line Items]                              
Common stock, shares authorized                       30,000,000 30,000,000    
Preferred stock, shares issued                       0 0    
Preferred stock, shares outstanding                       0 0    
Net proceeds from public offering | $               $ 9,900,000   $ 17,100,000          
Number of shares, granted                       17,800      
Shares issued, price per share | $ / shares                   $ 4.00          
Shares issued due to full-ratchet anti-dilution adjustment, shares                         1,156,487    
Fair value of warrants | $                       $ 391,108      
Common Stock [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                       100,000 28,971    
Shares issued due to full-ratchet anti-dilution adjustment, shares                         1,156,487    
2019 Senior Notes [Member]                              
Class of Stock [Line Items]                              
Shares issued, price per share | $ / shares                   4.00          
Number of common stock converted                 247,088            
Debt Instrument, Convertible, Conversion Price | $ / shares                 $ 3.60            
Debt Instrument, Convertible, Conversion Ratio                 0.10            
Fair value of warrants | $                         $ 197,403    
Common Stock [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                       1,321,132      
Number of shares, granted   17,800                          
Shares issued, price per share | $ / shares                   $ 4.00          
Shares issued due to full-ratchet anti-dilution adjustment, shares                         1,156,487    
Common Stock [Member] | Line of Credit [Member]                              
Class of Stock [Line Items]                              
Debt conversion converted, amount | $                   $ 700,000          
Debt conversion converted, shares                   199,537          
Common Stock [Member] | Underwritten Public Offering [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                   4,800,000          
Restricted Stock [Member]                              
Class of Stock [Line Items]                              
Number of shares, granted                       37,500 336,860    
Number of shares, forfeited                       10,706 23,804    
Number of shares, vested   12,500   55,143               281,721      
Restricted Stock [Member] | Underwritten Public Offering [Member]                              
Class of Stock [Line Items]                              
Number of shares, vested                   214,078          
Restricted Stock [Member] | Employment Termination [Member]                              
Class of Stock [Line Items]                              
Number of shares, forfeited                       1,530      
Restricted Stock [Member] | Federal, State and Local [Member]                              
Class of Stock [Line Items]                              
Number of shares, forfeited                       9,176 23,804    
Restricted Stock Units (RSUs) [Member]                              
Class of Stock [Line Items]                              
Number of shares, granted                       457,593      
Number of shares, forfeited                       4,000      
Number of shares, vested                       14,000      
Restricted Stock Units (RSUs) [Member] | 2019 Omnibus Incentive Plan [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                       14,300      
Employees [Member] | Restricted Stock [Member]                              
Class of Stock [Line Items]                              
Number of shares, granted             37,500                
Employees [Member] | Restricted Stock Units (RSUs) [Member]                              
Class of Stock [Line Items]                              
Number of shares, granted         202,930             144,457      
Number of shares, forfeited         4,000                    
Number of shares, vested 39,786                            
Consultants [Member]                              
Class of Stock [Line Items]                              
Options and warrants granted                       180,000      
Private Placement [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares               1,321,132              
Gross proceeds from issuance of common stock | $               $ 10,200,000              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                             79,268
Private Placement [Member] | Placement Agent [Member]                              
Class of Stock [Line Items]                              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights                             79,268
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares                             $ 9.30
Warrants and Rights Outstanding, Maturity Date                             Feb. 16, 2023
License Agreement [Member] | Ocuphire Pharma Inc [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares           44,689                  
License Agreement [Member] | Elion [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares   100,000                     825,000    
Payment for license grant | $                         $ 100,000    
License Agreement [Member] | Aposense [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                         625,000    
License Agreement [Member] | Yuhan [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                     250,000   250,000    
Sales Agreement [Member]                              
Class of Stock [Line Items]                              
Shares issued during period, shares                       21,597      
Gross proceeds from issuance of common stock | $                       $ 179,831      
Fair value of maximum offering shares | $     $ 30,000,000.0                        
Transaction costs, percentage     3.00%                        
Shares issued, price per share | $ / shares                       $ 8.33      
Service Vesting [Member] | Consultant [Member]                              
Class of Stock [Line Items]                              
Fair value of equity granted | $   $ 743,378                          
Subsequent Event [Member]                              
Class of Stock [Line Items]                              
Common stock, shares authorized                           50,000,000